Opportunity Information: Apply for PA 18 395
The Mentored Quantitative Research Development Award (Parent K25 - Clinical Trial Required), funding opportunity number PA 18 395, is a National Institutes of Health (NIH) career development grant designed to bring more quantitatively trained researchers into NIH-relevant health and biomedical research. Its central goal is to attract investigators who have strong backgrounds in quantitative science or engineering but whose prior work has not primarily focused on health, disease, or clinical research questions. In practice, this program is meant to help a productive quantitative professional pivot their skills into biomedical and clinical problem spaces by pairing them with experienced mentors and providing the structure and time needed to retrain, collaborate, and produce impactful, NIH-aligned research.
A defining feature of the K25 mechanism is the emphasis on mentored career development through a period of protected time. The award supports a supervised plan of study and research, allowing the recipient to deepen their understanding of biomedical or clinical domains while applying and extending their quantitative expertise. The opportunity specifically highlights applicants from fields such as mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering. The intent is not to fund a purely technical project in isolation, but to create a pathway where quantitative methods are integrated into health and disease research, building the recipient into an independent investigator who can operate comfortably across both quantitative and biomedical environments.
As indicated in the title, this particular parent announcement is the "Clinical Trial Required" version, which means the proposed career development and research plan is expected to include a clinical trial component consistent with NIH definitions and requirements. Applicants considering this opportunity typically need to ensure that their proposal aligns with NIH expectations for clinical trial conduct, oversight, and reporting, and that the mentoring team and institutional environment can support those responsibilities.
Eligibility to apply is broad at the organizational level. Eligible applicants include a wide range of U.S.-based entities such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) status, other than institutions of higher education); public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. For-profit organizations (other than small businesses) and small businesses are also listed as eligible, along with other categories captured under NIH eligibility rules.
The announcement also explicitly calls out additional eligible applicant types that NIH aims to include and encourage, such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. These categories reflect NIH's interest in broad participation across institution types and communities, including organizations that serve populations historically underrepresented in biomedical research.
At the same time, the opportunity draws clear boundaries around non-U.S. applicants. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" as defined in the NIH Grants Policy Statement are allowed, meaning a U.S. applicant organization can include certain well-justified international elements within the project under NIH rules, even though the primary applicant institution must be domestic.
From an administrative standpoint, this is a discretionary grant program under the NIH umbrella, with the funding activity category listed under a broad set of public-interest areas including education and health. The opportunity is associated with multiple CFDA numbers (now commonly referred to as Assistance Listing numbers), reflecting that it can be relevant across multiple NIH institutes and centers and therefore may align with a range of disease areas and research missions. The original closing date shown in the source data is 2019-01-07, and the record creation date is 2017-11-22; in real-world use, parent NIH announcements often have multiple receipt dates over time, so applicants typically confirm the currently active due dates and participating NIH institutes in the live listing and the NIH Guide notice history.
Overall, the K25 (Clinical Trial Required) is best understood as a mentored transition award: it is meant to help a quantitatively oriented scientist or engineer build biomedical and clinical trial research expertise while continuing to leverage their technical strengths, with enough protected time and mentoring support to develop into a competitive, independent NIH-funded investigator working on questions of health and disease.Apply for PA 18 395
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Quantitative Research Development Award (Parent K25 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, 93.866.
- This funding opportunity was created on 2017-11-22.
- Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PA 18 395) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Pathway to Independence Award (Parent K99/R00 - Clinical Trial Required) Apply for PA 18 397 Funding Number: PA 18 397 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Opportunities for Collaborative Research at the NIH Clinical Center (U01 - Clinical Trial Optional) Apply for PAR 18 646 Funding Number: PAR 18 646 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY18 Administrative Supplement (Admin Supp - Clinical Trial Optional) Apply for PA 18 676 Funding Number: PA 18 676 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) Apply for PA 18 720 Funding Number: PA 18 720 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Rare Diseases Clinical Research Consortia (RDCRC) for Rare Diseases Clinical Research Network (U54 Clinical Trials Optional) Apply for RFA TR 18 020 Funding Number: RFA TR 18 020 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Time-Sensitive Obesity Policy and Program Evaluation (R01 Clinical Trial Not Allowed) Apply for PAR 18 854 Funding Number: PAR 18 854 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 041 Funding Number: RFA NS 18 041 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed) Apply for RFA NS 18 042 Funding Number: RFA NS 18 042 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 046 Funding Number: RFA NS 18 046 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) Apply for RFA NS 18 043 Funding Number: RFA NS 18 043 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Predoctoral Training in Advanced Data Analytics for Behavioral and Social Sciences Research (BSSR) - Institutional Research Training Program [T32] Apply for RFA OD 19 011 Funding Number: RFA OD 19 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA NS 19 010 Funding Number: RFA NS 19 010 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed) Apply for RFA EB 18 003 Funding Number: RFA EB 18 003 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional) Apply for RFA NS 19 016 Funding Number: RFA NS 19 016 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain - (U44 Clinical Trial Not Allowed) Apply for RFA NS 19 020 Funding Number: RFA NS 19 020 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional) Apply for RFA NS 19 017 Funding Number: RFA NS 19 017 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,000,000 |
| Administrative Supplement for Research on Bioethical Issues Apply for PA 19 217 Funding Number: PA 19 217 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required) Apply for RFA NS 20 008 Funding Number: RFA NS 20 008 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required) Apply for RFA NS 20 010 Funding Number: RFA NS 20 010 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Developmental Centers for AIDS Research (P30 Clinical Trial Not Allowed) Apply for PAR 20 107 Funding Number: PAR 20 107 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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