Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional) | RFA CA 22 010

Opportunity Information: Apply for RFA CA 22 010

Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional) is an NIH/National Cancer Institute funding opportunity (RFA-CA-22-010) that supports revision applications to existing, currently funded NCI U2C Resource-Related Multi-Component Projects and Centers. The core idea is straightforward: if a U2C-funded center or multi-component resource project is already underway, NCI is offering a way to add a new, well-justified piece of work that meaningfully builds on the parent award. Specifically, the revision must either expand the original research questions or speed up progress toward the parent project goals by incorporating a new technology or instrument that was developed with support from the NCI Innovative Molecular Analysis Technologies (IMAT) program. In other words, this FOA is not for brand-new standalone projects; it is designed to strengthen and accelerate active U2C efforts by integrating an IMAT-originated tool or method.

A major purpose of the FOA is to push promising, emerging technologies beyond early development by encouraging independent validation and real-world use in the kinds of research communities that could benefit from them. NCI is signaling that IMAT-supported innovations should not stay stuck at the prototype or single-lab demonstration stage. Instead, they should be tested, validated, and made more broadly suitable within established cancer research resource environments. By tying these funds to revisions of existing U2C awards, NCI is leveraging mature infrastructures, established collaborations, and ongoing workflows to quickly evaluate whether a new instrument or technical approach truly performs as expected, scales appropriately, and produces reliable, reproducible results that can accelerate cancer research.

The mechanism is a cooperative agreement (U2C), which generally implies substantial NIH programmatic involvement compared to a standard grant. The activity area is listed under Education and Health, and the CFDA number is 93.394. The announcement also notes that clinical trials are optional, meaning the proposed revision work may include a clinical trial component if it is appropriate for the technology integration and the parent project scope, but a clinical trial is not required.

In terms of who can apply, eligibility is broad in general NIH terms, but the key practical requirement is that applicants must be tied to an active, currently funded NCI U2C Resource-Related Multi-Component Project or Center since this is a revision opportunity. The eligible applicant types include many common organizational categories such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district), as well as independent school districts and public housing authorities/Indian housing authorities. It also explicitly calls out additional eligible groups and institution types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and certain tribal governments and organizations. Non-U.S. (foreign) entities are also listed among other eligible applicants, reflecting NIH policy that can allow foreign components or foreign organizations in certain cases, though the parent U2C context and NCI requirements would still govern what is feasible.

Financially, the opportunity lists an award ceiling of $150,000. The original closing date provided is 2022-09-22, and the posting information indicates the FOA was created on 2022-01-03. The number of expected awards is not specified in the provided source data, suggesting awards depend on application volume, merit, and available funds rather than a fixed cohort size.

Overall, this FOA is best understood as a targeted accelerator: it helps existing NCI U2C centers and resource projects quickly adopt and rigorously test IMAT-developed technologies in ways that directly strengthen the parent award. The expected outcome is faster progress toward cancer research goals, better validated and more usable emerging tools, and stronger interdisciplinary collaboration around technology development and deployment within the cancer research ecosystem.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
• This funding opportunity was created on 2022-01-03.
• Applicants must submit their applications by 2022-09-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $150,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 22 010

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