NIDA Program Project Grant Applications (P01, Clinical Trial Optional) | PAR 18 425

Opportunity Information: Apply for PAR 18 425

The NIDA Program Project Grant Applications (P01, Clinical Trial Optional) opportunity (FOA number PAR-18-425) is a National Institutes of Health discretionary grant designed to fund large, coordinated research programs in areas that are high priority for the National Institute on Drug Abuse (NIDA). The core purpose is to support collaborative, multidisciplinary teams whose combined work produces clear scientific synergy, meaning the overall program achieves stronger, more impactful results than the same studies would if they were funded as separate, stand-alone research grants. In practice, this mechanism is meant for institutions and investigators who can organize multiple complementary research efforts around a shared set of addiction-related questions and demonstrate that the projects actively strengthen one another through shared concepts, methods, resources, data, or coordinated aims.

A defining feature of this program project mechanism is its required structure. Each funded program must include at least three highly meritorious research projects that operate together under one overarching program theme that directly advances NIDA's mission and goals. The expectation is not simply that three projects fall under a broad topic, but that they are intentionally integrated so that the combined approach offers substantial advantages, such as accelerating discovery, enabling cross-validation across studies, harmonizing measures for shared datasets, building shared infrastructure, or linking basic, translational, and clinical perspectives in a coordinated way. The "clinical trial optional" label indicates that applicants may propose clinical trials if appropriate to their scientific aims, but a clinical trial is not required for eligibility under this announcement.

The funding instrument is a grant under the P01 activity code, and the activity category listed for the opportunity is Education and Health under CFDA number 93.279. While the summary information provided does not specify an award ceiling or the expected number of awards, P01s are generally substantial, multi-project awards where review criteria heavily emphasize the added value of the program structure, the strength of each individual project, and the evidence that the projects together create outcomes that could not be achieved as efficiently or convincingly through separate awards.

Eligibility is broad and includes many types of U.S.-based applicant organizations. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions.

Foreign eligibility is more limited and follows NIH policy distinctions. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations are eligible to be included, and foreign components, as defined in the NIH Grants Policy Statement, are allowed. In other words, the applicant must be a domestic eligible organization, but the program can include certain foreign components when they are justified and consistent with NIH rules.

The source data indicates the opportunity was created on 2017-11-29 and lists an original closing date of 2019-08-16. Even if those dates are historical, the key takeaway for understanding the announcement is the scientific and organizational intent: NIDA is looking for integrated, multi-project programs where at least three projects jointly tackle critical addiction-related problems with clear coordination and measurable synergy, using a team science model that delivers more than the sum of its parts.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NIDA Program Project Grant Applications (P01, Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2017-11-29.
• Applicants must submit their applications by 2019-08-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 18 425

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