Opportunity Information: Apply for RFA AA 21 006
The Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) funding opportunity (RFA AA-21-006) is a discretionary NIH grant program run by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the Department of Health and Human Services. It supports the creation or continuation of large, multi-project research centers focused on alcohol-related science and public health impact. The intent is not to fund a single standalone study, but to build a coordinated center that can lead, organize, and accelerate interdisciplinary research by bringing together investigators, shared resources, and a coherent scientific vision under one umbrella. Because this is a P60 center mechanism, applicants are expected to show how multiple projects and cores will work together in a way that is stronger than the sum of individual parts.
The overall purpose of the program is to provide leadership in conducting and fostering collaborative research on topics that align with NIAAA's mission. The FOA highlights a broad scientific scope that can include the nature and causes of alcohol use disorder (AUD), including etiology and genetics; improved diagnosis; treatment development and testing; and prevention strategies. It also explicitly includes alcohol-related end organ diseases and their biomedical, psychosocial, and economic consequences. A key emphasis is that this work should be relevant across the lifespan (from youth through older adulthood) and attentive to racial and ethnic groups and other populations experiencing health disparities. In practice, this means a competitive center application would typically address both scientific innovation and real-world relevance, with a plan to generate knowledge that can translate into better prevention, clinical care, and policy or community responses.
A defining feature of this announcement is the requirement for a dissemination core. This core is expected to initiate and expand community education connected to the center's activities, making the center's science more accessible and usable beyond academia. The dissemination component signals that NIAAA wants these centers to function as hubs that not only produce research findings, but also communicate evidence in ways that can inform clinicians, community organizations, public health partners, and other stakeholders. Alongside dissemination, centers are also described as regional or national resources, meaning they are expected to contribute infrastructure, expertise, and leadership that helps advance the broader field. The FOA also notes an interest in developing new research methods, technologies, and approaches that sustain innovative, goal-directed research, reinforcing the expectation that centers will push the field forward in how alcohol research is done, not just what is studied.
The activity category is Health, and the associated CFDA number is 93.273. Clinical trials are optional under this FOA, so centers may include clinical trials if they fit the scientific plan, but they are not mandatory. This flexibility allows applications to range from basic and translational research to clinical and population-level studies, as long as the overall center theme and structure are cohesive and aligned with NIAAA priorities.
Eligibility is broad and includes many types of domestic organizations and governments. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; and small businesses. The FOA also references an "Others" category with additional eligibility details in the full announcement, indicating there may be further clarifications or conditions beyond the list.
In terms of funding scale and competitiveness, the opportunity lists an award ceiling of $1,250,000 and an expected number of awards of 5, indicating a limited number of relatively high-value center grants. The opportunity was created on April 5, 2021, with an original closing date of November 15, 2021. Even though these dates are historical for this specific posting, the structure and priorities described capture what NIAAA was seeking: comprehensive, collaborative alcohol research centers that combine strong science, shared infrastructure, and deliberate dissemination to communities and stakeholders, ultimately strengthening the national capacity to understand, prevent, and treat alcohol-related problems and their consequences.Apply for RFA AA 21 006
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Comprehensive Alcohol Research Centers (P60 Clinical trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Apr 05, 2021.
- Applicants must submit their applications by Nov 15, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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