Opportunity Information: Apply for RFA OD 20 006
The NIH funding opportunity "Small Research Grants for Analyses of Down Syndrome-related Research Data for the INCLUDE Project (R03 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA-OD-20-006) supports small, focused research projects that use existing Down syndrome-related datasets to generate new insights. It sits under the NIH INCLUDE Project, which is a broader effort aimed at improving health and quality of life for people with Down syndrome across the lifespan. The core idea is to encourage investigators to dig into already-available genomic and other "-omics" data (for example, genomics, transcriptomics, epigenomics, proteomics, metabolomics, and related high-dimensional datasets) to better understand why certain co-occurring health conditions develop in some individuals with Down syndrome and not others, and to identify factors that may contribute to resilience as well as risk.
This FOA is specifically geared toward analytical studies rather than collecting new clinical trial data, which is reflected in the mechanism and restriction: it uses the NIH R03 small grant mechanism and does not allow clinical trials. Projects are expected to be relatively compact in scope but scientifically strong, emphasizing careful, hypothesis-driven or discovery-driven analyses that can clarify underlying biological etiologies tied to co-occurring conditions. In practical terms, applications would typically center on reanalyzing existing datasets, integrating multiple -omics layers, applying statistical genetics or systems biology approaches, or performing computational analyses that connect molecular findings to health outcomes relevant to Down syndrome.
In addition to straightforward data analyses, the FOA allows applicants to propose the development of analytical approaches, tools, or algorithms, as long as they are appropriate for and clearly tied to analyzing Down syndrome-relevant data. That includes methods development work where the main deliverable is a validated computational approach, pipeline, or algorithm that improves how Down syndrome -omics data can be interpreted, integrated, or linked to clinically meaningful co-occurring conditions. The emphasis remains on enabling better understanding of mechanisms and pathways that influence health trajectories, rather than on conducting interventional studies.
Eligibility is broad and includes many typical NIH applicant categories such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various levels of government (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. The FOA also highlights eligibility for a range of mission-focused institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Federally recognized tribal governments and other tribal organizations are included as eligible applicants, and it also lists Indian/Native American Tribal Governments other than federally recognized as eligible under "Other Eligible Applicants."
On the international side, the rules are nuanced: non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the primary applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement. In other words, a U.S.-based applicant can include an eligible foreign component as part of the work when justified, but a foreign institution cannot serve as the main applicant for this FOA.
From an administrative standpoint, the opportunity is a discretionary NIH grant program and maps to multiple CFDA numbers (93.113, 93.121, 93.173, 93.233, 93.310, 93.837, 93.838, 93.839, 93.840, 93.853, 93.865, 93.866), reflecting the cross-cutting NIH involvement typical for INCLUDE-related activities. The opportunity record lists a creation date of 2019-12-13 and an original closing date of 2021-11-03. The listing does not provide an award ceiling or expected number of awards in the provided text, so those details would normally be confirmed by reviewing the full FOA and any related NIH notices.Apply for RFA OD 20 006
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Down Syndrome-related Research Data for the INCLUDE Project (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.233, 93.310, 93.837, 93.838, 93.839, 93.840, 93.853, 93.865, 93.866.
- This funding opportunity was created on 2019-12-13.
- Applicants must submit their applications by 2021-11-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Small Research Grants for Analyses of Down Syndrome-related Research Data for the INCLUDE Project (R03 Clinical Trial Not Allowed)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-OD-20-006.
What NIH initiative is this opportunity part of?
This opportunity sits under the NIH INCLUDE Project, which is a broader NIH effort focused on improving health and quality of life for people with Down syndrome across the lifespan.
What is the main purpose of this grant?
The main purpose is to support small, focused research projects that analyze existing Down syndrome-related datasets to generate new insights, particularly around biological mechanisms tied to co-occurring health conditions and factors related to resilience and risk.
What type of grant mechanism does this FOA use?
This FOA uses the NIH R03 small grant mechanism, which is intended for relatively compact projects that are tightly focused but scientifically strong.
Are clinical trials allowed under this FOA?
No. Clinical trials are not allowed under this funding opportunity (R03 Clinical Trial Not Allowed). The focus is on analytical studies rather than collecting new clinical trial data.
What kind of data is this FOA focused on?
The FOA emphasizes the use of existing Down syndrome-related datasets, especially genomic and other high-dimensional "-omics" datasets such as genomics, transcriptomics, epigenomics, proteomics, metabolomics, and related data types.
Does the FOA support projects that generate new data?
Based on the information provided, the FOA is geared toward analyzing already-available datasets rather than collecting new clinical trial data. The described intent is reanalysis and computational work using existing data.
What kinds of research questions are encouraged?
Projects are encouraged to investigate why certain co-occurring health conditions develop in some individuals with Down syndrome and not others, and to identify factors and pathways that may contribute to resilience as well as risk across the lifespan.
What types of analyses or approaches would fit this FOA?
Typical projects would center on reanalyzing existing datasets, integrating multiple -omics layers, applying statistical genetics or systems biology approaches, or conducting computational analyses that connect molecular findings to health outcomes relevant to Down syndrome.
Is methods or tool development allowed?
Yes. The FOA allows development of analytical approaches, tools, or algorithms, as long as the work is appropriate for and clearly tied to analyzing Down syndrome-relevant data.
If proposing a tool or algorithm, what should the deliverable look like?
The description indicates that methods development is appropriate when the main deliverable is a validated computational approach, pipeline, or algorithm that improves interpretation, integration, or linkage of Down syndrome -omics data to clinically meaningful co-occurring conditions.
Does this FOA prioritize hypothesis-driven projects, discovery-driven projects, or both?
Both are supported. The FOA highlights careful, hypothesis-driven or discovery-driven analyses, with emphasis on generating clarity about underlying biological etiologies tied to co-occurring conditions.
What is the overarching emphasis of funded work?
The emphasis remains on improving understanding of mechanisms and pathways that influence health trajectories in Down syndrome, rather than conducting interventional studies.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various government entities (state, county, city/township, and special districts), as well as independent school districts and public housing authorities/Indian housing authorities.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA highlights eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments and other tribal organizations are included as eligible applicants. The FOA also lists Indian/Native American Tribal Governments other than federally recognized under "Other Eligible Applicants."
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicants.
Can a foreign (non-U.S.) organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply as the primary applicant organization for this FOA.
Can a U.S. applicant include a foreign component in the project?
Yes. Non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement. This means a U.S.-based applicant can include an eligible foreign component when justified, even though a foreign institution cannot be the primary applicant.
What type of program is this from an administrative standpoint?
It is described as a discretionary NIH grant program.
Which CFDA numbers are associated with this opportunity?
The opportunity maps to multiple CFDA numbers: 93.113, 93.121, 93.173, 93.233, 93.310, 93.837, 93.838, 93.839, 93.840, 93.853, 93.865, and 93.866.
What does the presence of multiple CFDA numbers suggest?
Based on the provided description, the multiple CFDA numbers reflect cross-cutting NIH involvement typical for INCLUDE-related activities.
When was this opportunity record created?
The record lists a creation date of 2019-12-13.
What is the original closing date listed for this opportunity?
The original closing date listed is 2021-11-03.
Is an award ceiling stated in the information provided?
No. The provided text states that an award ceiling is not included in the listing excerpt.
Does the provided information say how many awards NIH expects to make?
No. The provided text indicates the expected number of awards is not shown in the excerpt and would typically require reviewing the full FOA and related NIH notices.
Where would an applicant normally verify missing details like award ceiling or number of awards?
The information provided notes that these details would normally be confirmed by reviewing the full FOA and any related NIH notices.
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| Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed) Apply for RFA OD 20 005 Funding Number: RFA OD 20 005 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Research on Autism Spectrum Disorders (R03 Clinical Trial Optional) Apply for PA 21 199 Funding Number: PA 21 199 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
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| Global Brain and Nervous System Disorders Research Across the Lifespan (R21 Clinical Trial Optional) Apply for PAR 21 319 Funding Number: PAR 21 319 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional) Apply for PAR 22 097 Funding Number: PAR 22 097 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed) Apply for PAR 23 171 Funding Number: PAR 23 171 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional) Apply for PAR 23 319 Funding Number: PAR 23 319 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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