Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed) | RFA AI 25 010

Opportunity Information: Apply for RFA AI 25 010

The Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed) funding opportunity (RFA-AI-25-010) is an NIH discretionary grant competition that will support, via a cooperative agreement mechanism, the continued operation of a centralized resource focused on immunology reagents tailored specifically for nonhuman primate (NHP) research. The core purpose is to strengthen rigor and reproducibility in NHP models by developing, producing, and distributing NHP-specific immunologic reagents that researchers need but cannot reliably obtain through normal commercial channels. In practice, this means making reagents that are either not sold commercially at all, or are technically available but not properly validated, optimized, or consistent enough for dependable use in NHP systems. By filling those gaps, the program aims to reduce variability across labs, improve comparability of results, and make preclinical NHP studies more interpretable and translatable.

The broader scientific goal is explicitly translational: accelerating the path toward cures, vaccines, and treatments for immune-mediated diseases, as well as emerging and reemerging infectious diseases. Because NHP models are often used when rodent or in vitro systems cannot adequately represent key aspects of human immunology, progress in this area can be limited by the lack of species-appropriate antibodies, assays, standards, and other immune-monitoring tools. This resource is intended to serve as enabling infrastructure for the research community, so investigators can run more robust immune profiling, mechanistic studies, and preclinical evaluations in NHPs without having to individually invent, validate, and quality-control critical reagents on a lab-by-lab basis.

The award uses a U24 cooperative agreement, which generally indicates substantial NIH scientific and/or programmatic involvement compared to a typical research project grant. While the specific collaboration structure is not detailed in the text provided, applicants should typically expect an approach that includes active coordination with NIH program staff, clear milestones, and strong expectations for community-facing operations such as distribution, documentation, and support. The activity category is Health, and the CFDA listing associated with the opportunity is 93.855. Clinical trials are not allowed under this notice, which means the supported work should remain in the realm of reagent development, validation, production, and dissemination, along with related non-clinical research activities that enable preclinical NHP studies rather than testing interventions in human participants.

A wide range of domestic U.S. organizations are eligible to apply. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. Federally recognized Native American tribal governments are eligible, as are tribal organizations that are not federally recognized tribal governments. The announcement also notes additional eligible applicant types such as eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, eligibility is clearly limited to U.S.-based entities: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. In effect, applicants need to be able to propose and carry out the work entirely within allowable domestic organizational structures and locations, without relying on foreign subcomponents that NIH would consider a foreign component.

Key dates provided include a creation date of 2025-09-04 and an original application closing date of 2025-10-28. The listing does not specify an award ceiling, expected number of awards, or other budget parameters in the excerpt provided, so applicants would need to consult the full NOFO package for details on allowable costs, project period, and any caps or administrative requirements. Overall, this opportunity is best understood as NIH support for a national-scale, community-serving NHP immunologic reagent resource, designed to make NHP-based immunology and infectious disease research more standardized, reproducible, and efficient by ensuring access to high-quality, fit-for-purpose reagents that investigators can depend on.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
• This funding opportunity was created on 2025-09-04.
• Applicants must submit their applications by 2025-10-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AI 25 010

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: