Opportunity Information: Apply for PA 20 206
The Mentored Patient-Oriented Research Career Development Award (K23) is an NIH career development grant designed to help clinically trained investigators build a long-term research career centered on patient-oriented research. It is meant for individuals who already hold a clinical doctoral degree and have clearly committed to conducting research that directly involves human subjects, patient populations, or clinical phenomena. The overall goal is to provide a structured, mentored path that helps a developing clinician-researcher gain the skills, experience, and publication track record needed to become an independent investigator, typically by combining a supervised research project with a formal career development and training plan.
This specific opportunity is the "Parent K23 - Independent Clinical Trial Required" (Funding Opportunity Number PA-20-206), which signals that the proposed work is expected to include an independent clinical trial as a central component. In practice, this means the applicant is not only conducting patient-oriented research, but is also taking responsibility for designing and leading a clinical trial in a way that meets NIH expectations for independent trial leadership. The K23 structure emphasizes mentored development, so applicants generally propose a primary mentor and often a team of co-mentors who provide complementary expertise (for example, clinical content, trial methodology, biostatistics, implementation, or ethics), along with a training plan that addresses any gaps in the applicant's preparation.
The award is offered by the National Institutes of Health (NIH) and uses the grant funding instrument. It falls under broad public assistance activity categories that include health, education, and human services. Multiple NIH CFDA numbers are associated with the announcement (including 93.113, 93.121, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.859, 93.865, and 93.866), reflecting that many NIH Institutes and Centers may participate depending on the disease area or research focus.
Eligibility is broad at the organizational level. A wide range of U.S.-based entities can apply, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), excluding higher education institutions when specified); for-profit organizations other than small businesses; small businesses; and other eligible applicants. The announcement also highlights several categories of institutions and organizations that are explicitly included as eligible applicants, such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. This emphasis reflects NIH's intent to ensure that a diverse range of institutions can host and support mentored clinical investigators, including those in underserved or historically underrepresented settings.
Restrictions apply to non-U.S. organizations. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as the applicant organization. However, foreign components are allowed when they meet NIH's definition in the NIH Grants Policy Statement. In practical terms, that means the primary applicant organization must be eligible and domestic, but certain project elements can include a foreign component if it is well justified scientifically and administratively and complies with NIH policy.
Key administrative details included in the source data are that the opportunity is discretionary, was created on 2020-05-12, and listed an original closing date of 2024-05-07. The provided listing does not specify an award ceiling or the expected number of awards, which often varies by NIH Institute/Center, budget availability, and application volume. Overall, this K23 announcement is best understood as a mentored, career-building mechanism for clinician-scientists who want to become independent leaders in patient-oriented research and who are prepared to take on the responsibilities of conducting an independent clinical trial within a mentored career development framework.Apply for PA 20 206
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.859, 93.865, 93.866.
- This funding opportunity was created on 2020-05-12.
- Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Mentored Patient-Oriented Research Career Development Award (K23) - Independent Clinical Trial Required (PA-20-206)
What is the K23 Mentored Patient-Oriented Research Career Development Award?
The K23 is an NIH career development grant intended to help clinically trained investigators build a long-term research career focused on patient-oriented research. It supports a structured, mentored path that typically combines a supervised research project with a formal career development and training plan, with the goal of helping the candidate become an independent investigator.
What is this specific K23 funding opportunity?
This opportunity is the "Parent K23 - Independent Clinical Trial Required" with Funding Opportunity Number (FON) PA-20-206. It is a K23 mechanism where the proposed work is expected to include an independent clinical trial as a central component.
Who is the intended applicant for this K23 opportunity?
It is meant for individuals who already hold a clinical doctoral degree and have clearly committed to conducting patient-oriented research. The research should directly involve human subjects, patient populations, or clinical phenomena.
What does "patient-oriented research" mean in this context?
Based on the description provided, patient-oriented research is research that directly involves human subjects, patient populations, or clinical phenomena.
What does "Independent Clinical Trial Required" mean for PA-20-206?
It means the applicant is expected to design and lead an independent clinical trial as a central component of the proposed work, taking responsibility for clinical trial leadership in a manner that meets NIH expectations.
Is this award meant for independent investigators already running their own lab?
The K23 is described as a mentored, career-building mechanism for developing clinician-researchers. Its goal is to help the candidate gain skills, experience, and a publication track record needed to become an independent investigator, implying it is positioned as a pathway toward independence rather than for fully established independence.
What are the major components of a typical K23 plan under this announcement?
The structure emphasizes mentored development. Applicants generally propose (1) a supervised research project and (2) a formal career development and training plan. The training plan is intended to address gaps in the applicant's preparation.
Do applicants need a mentor?
Yes. The K23 structure emphasizes mentored development. Applicants generally propose a primary mentor and often a team of co-mentors.
Why would someone include co-mentors, and what expertise might they cover?
Co-mentors are often included to provide complementary expertise. Examples listed include clinical content, trial methodology, biostatistics, implementation, or ethics.
What agency offers this opportunity?
The award is offered by the National Institutes of Health (NIH).
What funding instrument is used for this opportunity?
This opportunity uses the grant funding instrument.
What public assistance activity categories does this opportunity fall under?
It falls under broad public assistance activity categories that include health, education, and human services.
Which NIH program areas or Institutes/Centers participate?
The announcement is associated with multiple NIH CFDA numbers (including 93.113, 93.121, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.859, 93.865, and 93.866). This indicates that many NIH Institutes and Centers may participate depending on the disease area or research focus.
What types of U.S. organizations are eligible to apply?
Eligibility is broad at the organizational level. Eligible U.S.-based entities listed include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), excluding higher education institutions when specified); for-profit organizations other than small businesses; small businesses; and other eligible applicants.
Are minority-serving institutions and community-based organizations eligible?
Yes. The announcement explicitly includes multiple categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations as eligible applicants.
Are U.S. territories or possessions eligible applicants?
Yes. U.S. territories or possessions are explicitly highlighted among eligible applicant categories.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are listed among the categories explicitly included as eligible applicants.
Can a non-U.S. organization apply as the applicant organization?
No. Non-domestic (non-U.S.) entities are not eligible to apply as the applicant organization for this opportunity.
Can the non-U.S. component of a U.S. organization serve as the applicant?
No. Non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as the applicant organization.
Are foreign components allowed at all?
Yes. Foreign components are allowed when they meet NIH's definition in the NIH Grants Policy Statement. In practical terms, the primary applicant organization must be eligible and domestic, but certain project elements may include a foreign component if it is justified and complies with NIH policy.
Is this opportunity discretionary?
Yes. The source data indicates this opportunity is discretionary.
When was this opportunity created?
The listing indicates it was created on 2020-05-12.
What is the closing date listed for this opportunity?
The source data lists an original closing date of 2024-05-07.
Does the listing provide an award ceiling?
No. The provided listing does not specify an award ceiling.
Does the listing say how many awards will be made?
No. The provided listing does not specify the expected number of awards. It notes that this often varies by NIH Institute/Center, budget availability, and application volume.
What is the overall goal of this K23 announcement?
The overall goal is to provide a structured, mentored path that helps a developing clinician-researcher gain skills, experience, and a publication track record needed to become an independent investigator, while leading an independent clinical trial within a mentored career development framework.
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| Funding Opportunity |
|---|
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) Apply for PA 20 205 Funding Number: PA 20 205 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) Apply for PA 20 203 Funding Number: PA 20 203 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Apply for PA 20 222 Funding Number: PA 20 222 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplement for Research on Dietary Supplements (Admin Supp-Clinical Trial Not Allowed) Apply for PA 20 227 Funding Number: PA 20 227 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,000,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 20 242 Funding Number: PA 20 242 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 20 246 Funding Number: PA 20 246 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 20 245 Funding Number: PA 20 245 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 20 248 Funding Number: PA 20 248 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity) Apply for PA 20 251 Funding Number: PA 20 251 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 20 261 Funding Number: PA 20 261 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2020-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 20 262 Funding Number: PA 20 262 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2020-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 20 260 Funding Number: PA 20 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 20 265 Funding Number: PA 20 265 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Successor-in-Interest (Type 6 Parent Clinical Trial Optional) Apply for PA 20 275 Funding Number: PA 20 275 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 21 051 Funding Number: PA 21 051 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 21 050 Funding Number: PA 21 050 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity) Apply for PA 21 052 Funding Number: PA 21 052 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 21 049 Funding Number: PA 21 049 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 21 048 Funding Number: PA 21 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) Apply for PAR 21 038 Funding Number: PAR 21 038 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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